Project Research Scientist – I

Project Research Scientist -I (Bioinformatician) - ICMR CAR MANASI Project Identifying genetic factors underlying maternal de novo lipogenesis (DNL) and infant body fat and its interaction with gut microbiome.

.Perform genome-wide association studies (GWAS) using large-scale genotypic and phenotypic datasets. .Conduct Mendelian randomization analyses using the UK Biobank dataset and infer causal relationships between genetic variants, biomarkers, and disease outcomes. .Develop, validate, and apply polygenic risk scores (PRS) for prediction of disease risk and stratification of individuals. .Process and analyze microbiome whole metagenome sequencing data, including taxonomic profiling, diversity metrics, and functional pathway analysis. .Implement rigorous data quality control, imputation, and statistical modeling pipelines. .Collaborate with project coordinators, molecular biologists, nutrition scientists, and clinicians to interpret bioinformatics results in a translational context. .Maintain and document reproducible workflows using open-source bioinformatics/statistical tools (e.g., PLINK, R, Python, MR-Base, QIIME). .Contribute to preparation of publications, reports, presentations, and grant deliverables. .Support the development of a project-specific database/knowledge base integrating genetic, microbiome, and clinical information.